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Interactions among ventilation, the circulation, and the uptake and distribution of halothane--use of a hybrid computer multiple model: II. Spontaneous vs. controlled ventilation, and the effects of CO2.

Authors
  • Fukui, Y
  • Smith, N T
Type
Published Article
Journal
Anesthesiology
Publication Date
Feb 01, 1981
Volume
54
Issue
2
Pages
119–124
Identifiers
PMID: 6781381
Source
Medline
Language
English
License
Unknown

Abstract

The authors have described a basic hybrid computer multiple model of the circulation, ventilation, and uptake and distribution of halothane in a companion paper. A multiple model consists of two or more submodels, each of which is complete in itself and could operate independently. In a multiple model, however, each submodel interacts with the others. The present paper describes the addition of a CO2-control loop (submodel), through which the partial pressure of CO2 modulates ventilation, as well a myocardial "contractility," arterial pressure, cardiac output, and regional vascular resistances. The concentration of halothane modifies these CO2-induced modulations. The CO2- and halothane-induced changes in ventilation and circulation in turn modify the uptake and distribution of halothane. Thus, a complex set of interrelationships among the submodels and compartments exists.

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