Affordable Access

Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study.

Authors
  • Schanck, A
  • Mingeot-Leclercq, M P
  • Tulkens, P M
  • Carrier, D
  • Smith, I C
  • Jarrell, H C
Type
Published Article
Journal
Chemistry and Physics of Lipids
Publisher
Elsevier
Publication Date
Sep 01, 1992
Volume
62
Issue
2
Pages
153–163
Identifiers
PMID: 1423808
Source
Medline
License
Unknown

Abstract

The effect of several aminoglycoside (AG) antibiotics on aqueous multilamellar dispersions of mixtures of phosphatidylinositol (PI) and deuterated phosphatidylcholine (PC) has been studied by deuterium (2H) NMR. Isepamicin and amikacin gave rise to no significant changes in 2H-NMR lineshape relative to that of the lipid mixture without antibiotic. Both kanamycin A and B, which have a greater affinity for PI than the other two antibiotics examined in this study, induced temperature-dependent changes in 2H-NMR lineshapes and associated spectral moments. The results are consistent with an antibiotic-induced lateral phase separation giving rise to PC-enriched domains free of drug and PI-AG domains. These effects are correlated with the inhibitory potency of aminoglycosides towards PC degradation.

Report this publication

Statistics

Seen <100 times