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Interaction of tryptophan and related compounds with oxygen- and carbon-centered radicals.

Authors
  • Sverdlov, R L
  • Brinkevich, S D
  • Shadyro, O I
Type
Published Article
Journal
Free Radical Research
Publisher
Informa UK (Taylor & Francis)
Publication Date
Oct 01, 2014
Volume
48
Issue
10
Pages
1200–1205
Identifiers
DOI: 10.3109/10715762.2014.944181
PMID: 25030296
Source
Medline
Keywords
License
Unknown

Abstract

Effects of tryptophan, 5-hydroxytryptophan, serotonin, and melatonin on final product formation during radiolysis of deaerated and oxygen-saturated ethanol and aqueous 1M ethanol solutions were studied. The named amino acids were found to be capable of adding α-hydroxyethyl radicals, thereby suppressing recombination reactions of these species. Unlike melatonin, tryptophan, 5-hydroxytryptophan, and serotonin were able to reduce oxygen-centered radicals being formed on radiation-chemical oxidation of ethanol in the presence of oxygen via electron transfer from the amine nitrogen lone pair.

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