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Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein.

Authors
  • Mousli, M1
  • Bronner, C
  • Bockaert, J
  • Rouot, B
  • Landry, Y
  • 1 Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur, Strasbourg I, France. , (France)
Type
Published Article
Journal
Immunology Letters
Publisher
Elsevier
Publication Date
Sep 01, 1990
Volume
25
Issue
4
Pages
355–357
Identifiers
PMID: 1701162
Source
Medline
License
Unknown

Abstract

Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their alpha subunits prevented the increase in GTPase activity induced by substance P, compound 48/80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of alpha subunits of G proteins by mimicking the agonist-liganded receptors.

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