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The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.

Authors
Type
Published Article
Journal
BMC Cancer
1471-2407
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Pages
85–85
Identifiers
PMID: 17511879
Source
Medline
License
Unknown

Abstract

The identification and characterization of the interaction of BRCA1 with PP1 and detection of changes in the expression of PP1 and genes encoding other BRCA1 associated proteins identifies important genetic pathways that may be significant to breast tumorigenesis. Alterations in the expression of genes, particularly phosphatases that operate in association with BRCA1, could negatively affect the function of BRCA1 or BRCA1 associated proteins, contributing to the development of breast cancer.

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