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[The interaction of mu-opioid receptors with ion channels and G-proteins].

Authors
Type
Published Article
Journal
Eksperimental'naia i klinicheskaia farmakologiia
Publication Date
Volume
69
Issue
2
Pages
62–74
Identifiers
PMID: 16845945
Source
Medline

Abstract

The state-of-the-art in investigations of the mu-opioid receptors (ORs) is reviewed. Published information on the interaction between mu-ORs and various G-proteins is summarized and data on the neutral antagonists and inverse agonists of mu-opioid receptor are generalized. The notions about the spontaneous activation of mu-ORs are considered and numerous reports on the interaction between mu-ORs and GIRK, KATP, and Kv channels are analyzed. The role of L, N, and P/Q types of Ca(2+)-channels in mu-OR-mediated intracellular signaling is discussed.

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