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Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium.

Authors
  • Ma, Yiyi1
  • Follis, Jack L2
  • Smith, Caren E3
  • Tanaka, Toshiko4
  • Manichaikul, Ani W5
  • Chu, Audrey Y6
  • Samieri, Cecilia7
  • Zhou, Xia8
  • Guan, Weihua9
  • Wang, Lu6
  • Biggs, Mary L10
  • Chen, Yii-Der I11
  • Hernandez, Dena G12
  • Borecki, Ingrid13
  • Chasman, Daniel I6
  • Rich, Stephen S5
  • Ferrucci, Luigi4
  • Irvin, Marguerite Ryan14
  • Aslibekyan, Stella14
  • Zhi, Degui15
  • And 27 more
  • 1 Biomedical Genetics, Department of Medicine, Boston University, Boston, MA; Jean Mayer USDA Human Nutrition Research Center on Aging and [email protected]
  • 2 Department of Mathematics, Computer Science and Cooperative Engineering, University of St. Thomas, Houston, TX;
  • 3 Jean Mayer USDA Human Nutrition Research Center on Aging and.
  • 4 Translational Gerontology Branch and.
  • 5 Center for Public Health Genomics, University of Virginia, Charlottesville, VA;
  • 6 Brigham and Women's Hospital, Harvard Medical School, Boston, MA;
  • 7 Inserm, U897, University of Bordeaux, Bordeaux, France; University of Bordeaux, ISPED, Bordeaux, France;
  • 8 Divisions of Epidemiology and Community Health and.
  • 9 Biostatistics, School of Public Health, and.
  • 10 Departments of Biostatistics, Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA;
  • 11 Cedars-Sinai Medical Center, Medical Genetics Research Institute, Los Angeles, CA; Los Angeles Biomedical Institute, Harbor-University of California, Los Angeles Medical Center, Torrance, CA;
  • 12 Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD;
  • 13 Department of Genetics, Washington University School of Medicine, St. Louis, MO;
  • 14 Departments of Epidemiology and.
  • 15 Biostatics, University of Alabama at Birmingham, Birmingham, AL;
  • 16 Department of Medicine, Vanderbilt University, Nashville, TN;
  • 17 Inserm, UMR1167, Lille, France; University of Lille, Lille, France; Institut Pasteur de Lille, Lille, France; Regional University Hospital of Lille, Lille, France;
  • 18 Inserm, UMR1167, Lille, France; University of Lille, Lille, France; Institut Pasteur de Lille, Lille, France;
  • 19 Epidemiology, Health Services, and Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA;
  • 20 Department of Internal Medicine, University of New Mexico, Albuquerque, NM;
  • 21 Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA;
  • 22 Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy;
  • 23 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN;
  • 24 Departments of Internal Medicine and.
  • 25 Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC;
  • 26 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA;
  • 27 New York Academy of Medicine, New York, NY;
  • 28 Hudson Alpha Institute for Biotechnology, Huntsville, AL;
  • 29 Jean Mayer USDA Human Nutrition Research Center on Aging and Department of Epidemiology and Population Genetics, Cardiovascular Research Center, Madrid, Spain; and IMDEA Food Institute, Madrid, Spain.
Type
Published Article
Journal
American Journal of Clinical Nutrition
Publisher
Oxford University Press
Publication Date
February 2016
Volume
103
Issue
2
Pages
567–578
Identifiers
DOI: 10.3945/ajcn.115.112987
PMID: 26791180
Source
Medline
Keywords
License
Unknown

Abstract

We obtained little evidence that the gene-by-fatty acid interactions on blood lipids act through DNA methylation.

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