[Interaction of methimazole and quinones. Spectrophotometric determination of methimazole in blood].
- Published Article
- Publication Date
Apr 14, 1983
A sensitive method for spectrophotometric determination of methimazole is based on the reaction of this compound with 2,3-dichloro-1,4-naphtoquinone in presence of ammonia. The colour thus formed is stable, reproducible and linear in the range 0,4 to 4 micrograms/ml of methimazole concentration. This method has been employed successfully for estimation of the antithyroid drug in plasma sample with good recovery (75 +/- 2%). The colour is due to formation of a red compound of molecular formula C14H11O2N3S, deduced from elemental analysis and mass spectrum.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6843873