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[Interaction of the lymph node and splenic lymphocytes of mice in inactivation of allogeneic hematopoietic stem cells].

Authors
Type
Published Article
Journal
Biulleten' eksperimental'noĭ biologii i meditsiny
Publication Date
Volume
99
Issue
5
Pages
592–594
Identifiers
PMID: 3890981
Source
Medline
License
Unknown

Abstract

A study was made of interaction of mouse spleen and lymph node lymphocytes in inactivation of allogeneic stem cells. It was established that T lymphocytes of the lymph nodes and spleen lymphocytes do not interact on combined administration; their action is of additive nature. B lymphocytes of the lymph nodes have a regulating activity both in respect to T lymphocytes of the lymph nodes and lymphocytes of the spleen. The stem cells serve as target. Depending on the stem cells/B lymphocytes ratio B lymphocytes are capable of exerting either helper or suppressor action.

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