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The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision.

Authors
  • Smith, C
  • McEwan, A I
  • Jhaveri, R
  • Wilkinson, M
  • Goodman, D
  • Smith, L R
  • Canada, A T
  • Glass, P S
Type
Published Article
Journal
Anesthesiology
Publication Date
Oct 01, 1994
Volume
81
Issue
4
Identifiers
PMID: 7943832
Source
Medline
License
Unknown

Abstract

We defined the propofol concentration required for loss of consciousness and showed that it is reduced by increasing fentanyl concentration and by increasing age. The propofol concentration (alone) adequate for skin incision is high but is markedly reduced by fentanyl. A ceiling effect in the Cp50i for propofol is seen with fentanyl concentrations greater than 3 ng/ml.

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