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[Interaction of DNA with benzocrown derivatives of actinocin].

Authors
  • Moroshkina, E B
  • Zagoruĭko, N V
  • Glibin, E N
Type
Published Article
Journal
Molekuliarnaia biologiia
Publication Date
Jan 01, 2001
Volume
35
Issue
1
Pages
109–116
Identifiers
PMID: 11234368
Source
Medline
License
Unknown

Abstract

Complexes of DNA with actinocin derivatives containing benzocrown groups at the 1 and/or 9 positions of the chromophore were studied by spectrophotometric titration and circular dichroism. The actinocin chromophore and the crown fragments are the binding sites of the ligands with DNA. The mode of ligand-DNA binding is shown to depend on the size of the crown group, its distance to the actinocin chromophore, and the ionic strength of the medium. Selective toward Na+ ion benzocrown fragments combine with DNA phosphate groups. The simultaneous interaction of the actinocin chromophore with the DNA bases is possible only at optimal distance between both the binding sites of ligand molecule.

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