Using a cue-target paradigm, this study investigated the interaction between location and frequency information processing in human auditory inhibition of return (IOR). The cue and the target varied in terms of location and frequency and participants were asked to perform a target detection, localization or frequency discrimination task. Results showed that, when neither location nor frequency of auditory stimuli was particularly relevant to the target detection task, there was a location-based IOR only if the cue and the target were identical in frequency and there was a frequency-based IOR only if the cue and the target were presented at the same location. When a particular feature of auditory stimuli, whether location or frequency, was directly relevant to the current task, the IOR effect was evident for this feature only if the cue and the target differed on the task-irrelevant feature, while the IOR effect was eliminated for the task-relevant feature when the cue and the target had the same task-irrelevant feature. Similarly, the IOR effect based on the task-irrelevant feature was evident when the cue and the target differed on the task-relevant feature, and was eliminated or reversed when the cue and the target shared the task-relevant feature. Theoretical implications of these findings for auditory IOR are discussed.