Affordable Access

deepdyve-link
Publisher Website

The interaction between detectable plasma viral load and increased body mass index on hypertension among persons living with HIV.

Authors
  • Xu, Yunan1, 2
  • Chen, Xinguang1
  • Zhou, Zhi1
  • Morano, Jamie3
  • Cook, Robert L1
  • 1 Department of Epidemiology, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • 2 Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
  • 3 Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Type
Published Article
Journal
AIDS care
Publication Date
Jul 01, 2020
Volume
32
Issue
7
Pages
890–895
Identifiers
DOI: 10.1080/09540121.2019.1668521
PMID: 31530006
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Increased body mass index (BMI) and HIV are each associated with hypertension. This study tested interactions between BMI and detectable plasma viral load (pVL) on hypertension among 659 persons living with HIV (PLWH). All participants were categorized into four subgroups based on BMI (<25 and ≥25 kg/m2) and pVL (<200 and ≥200 copies/ml). Multiplicative interaction was assessed using logistic regression; addictive interaction was assessed using three measures: Relative Excess Risk due to Interaction (RERI), Attributable Proportion (AP), and Synergy index (S). Compared to the participants with normal BMI and undetectable pVL, those who had increased BMI with an undetectable pVL had an elevated risk of hypertension with OR [95%CI] = 1.80 [1.02, 3.20]; the risk was further increased for those who had increased BMI with detectable pVL with OR [95%CI] = 3.54 [1.71, 7.31]. The multiplicative interaction was significant (p = 0.01). Results from additive interaction indicated RERI [95%CI] =1.89 [0.76, 4.79] and AP [95%CI] = 0.64 [0.32, 0. 95]. The interaction effects of increased BMI and detectable pVL on hypertension on both multiplicative and additive scales suggested that PLWH with increased BMI and detectable pVL should be intensively managed and monitored for hypertension prevention and treatment.

Report this publication

Statistics

Seen <100 times