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Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis.

Authors
  • Hedström, Anna Karin
  • Lima Bomfim, Izaura
  • Barcellos, Lisa
  • Gianfrancesco, Milena
  • Schaefer, Catherine
  • Kockum, Ingrid
  • Olsson, Tomas
  • Alfredsson, Lars
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Mar 11, 2014
Volume
82
Issue
10
Pages
865–872
Identifiers
DOI: 10.1212/WNL.0000000000000203
PMID: 24500647
Source
Medline
License
Unknown

Abstract

We observed striking interactions between BMI status and HLA genotype with regard to MS risk. Hypothetically, a low-grade inflammatory response inherent to obesity synergizes with the adaptive, HLA molecule-restricted arm of the immune system, causing MS. Prevention of adolescent obesity may thus lower the risk of developing MS, predominantly among people with a genetic susceptibility to the disease.

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