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Inter-ethnic differences--how important is it in cancer treatment?

Authors
Type
Published Article
Journal
Annals of the Academy of Medicine, Singapore
Publication Date
Volume
40
Issue
8
Pages
356–361
Identifiers
PMID: 22065001
Source
Medline

Abstract

It is now well recognised that there are inter-ethnic differences accounting for variations in both pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, resulting in differences in drug responses. Treating physicians should be aware of pharmacogenetic differences that may exist between the races while extrapolating data generated from other populations to their own patients in order to ensure optimal treatment response and minimise toxicity. This is especially crucial in the practice of oncology where many anti-cancer drugs have narrow therapeutic indices. This paper discusses some commonly used drugs in cancer treatment where inter-ethnic differences in drug safety and efficacy are known to exist that are relevant to the Asian physician.

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