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Inter-alpha-trypsin inhibitor-related immunoreactivity in human tissues and body fluids.

Authors
  • Businaro, R
  • Leali, F M
  • De Renzis, G
  • Pompili, E
  • Pagliari, G
  • Menghi, G
  • Fumagalli, L
Type
Published Article
Journal
Cellular and molecular biology
Publication Date
Jul 01, 1992
Volume
38
Issue
4
Pages
463–471
Identifiers
PMID: 1379887
Source
Medline
License
Unknown

Abstract

The distribution of inter-alpha-trypsin inhibitor (ITI) and related inhibitors was investigated in normal human tissues and body fluids by using an enzyme-linked immunosorbent assay (ELISA) and a streptavidin-biotin-peroxidase immunohistochemical technique. ITI-related immunoreactivity was localized in different cell types of various organs, such as liver, kidney, testis, gross intestine, cutis and brain. Specific immunoreactivity was also detected in serum, urine and bronchial mucus. This widespread, but not ubiquitous pattern of localization suggests that, in addition to the well known plasmatic role, ITI and/or ITI-related inhibitors may play a number of different physiological roles in various human tissues.

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