Introduction: In conjunction with a patient suffering from sepsis, ongoing processes in the body affects the brain. Patients can suffer from a state of confusion known as delirium. Aim: The aim of the study was to describe critical care nursing care associated with sepsis-associated delirium. Method: To conduct the study we selected systematic literature method. To conduct the study were selected systematic literature. Data were searched three databases and free-text search and manual search of reference lists of articles. An integrated analysis was performed to compile the results. Results: The result is based on four articles. The result appeared in three main categories: Perform personcentered care, Perform targeted drug treatment and Conditions for good care. Conclusion: There is a lack of knowledge on the subject of health professionals which leads to patients diagnosed late or missed diagnosis, which in turn leads to increased morbidity, mortality and prolonged hospitalization.