Affordable Access

deepdyve-link
Publisher Website

Integrity of the cone photoreceptor mosaic in oligocone trichromacy.

Authors
  • Michaelides, Michel
  • Rha, Jungtae
  • Dees, Elise W
  • Baraas, Rigmor C
  • Wagner-Schuman, Melissa L
  • Mollon, John D
  • Dubis, Adam M
  • Andersen, Mette K G
  • Rosenberg, Thomas
  • Larsen, Michael
  • Moore, Anthony T
  • Carroll, Joseph
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Jun 01, 2011
Volume
52
Issue
7
Pages
4757–4764
Identifiers
DOI: 10.1167/iovs.10-6659
PMID: 21436275
Source
Medline
License
Unknown

Abstract

Findings are consistent with the visual deficits being caused by a reduced number of healthy cones in the two brothers and the adult female. In the unrelated adult subject, no structural basis for the disorder was found. These data suggest two distinct groups on the basis of structural imaging. It is proposed that the former group with evidence of a reduction in cone numbers is more in keeping with typical OT, with the latter group representing an OT-like phenotype. These two groups may be difficult to readily discern on the basis of phenotypic features alone, and high-resolution imaging may be an effective way to distinguish between these phenotypes.

Report this publication

Statistics

Seen <100 times