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Integrative approaches for finding modular structure in biological networks.

Authors
Type
Published Article
Journal
Nature Reviews Genetics
Publisher
Springer Nature
Volume
14
Issue
10
Pages
719–732
Identifiers
DOI: 10.1038/nrg3552
Source
Ideker Lab
License
Unknown

Abstract

A central goal of systems biology is to elucidate the structural and functional architecture of the cell. To this end, large and complex networks of molecular interactions are being rapidly generated for humans and model organisms. A recent focus of bioinformatics research has been to integrate these networks with each other and with diverse molecular profiles to identify sets of molecules and interactions that participate in a common biological function - that is, modules . Here, we classify such integrative approaches into four broad categories, describe their bioinformatic principles and review their applications.

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