Affordable Access

deepdyve-link
Publisher Website

Integrating the roles of liver X receptors in inflammation and infection: mechanisms and outcomes.

Authors
  • Glaría, Estibaliz1
  • Letelier, Nicole A1
  • Valledor, Annabel F2
  • 1 Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain. , (Spain)
  • 2 Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, 08028 Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Current opinion in pharmacology
Publication Date
Jun 26, 2020
Volume
53
Pages
55–65
Identifiers
DOI: 10.1016/j.coph.2020.05.001
PMID: 32599447
Source
Medline
Language
English
License
Unknown

Abstract

Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of metabolic and anti-inflammatory actions that result in the modulation of immune responses and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This review gives an overview of the recent advances in understanding the complexity of the mechanisms through which the LXR pathway controls inflammation and host-cell pathogen interaction. Copyright © 2020 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times