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Integrating chemical and mechanical signals in neural crest cell migration.

Authors
  • Shellard, Adam1
  • Mayor, Roberto2
  • 1 Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
  • 2 Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: [email protected]
Type
Published Article
Journal
Current opinion in genetics & development
Publication Date
Aug 01, 2019
Volume
57
Pages
16–24
Identifiers
DOI: 10.1016/j.gde.2019.06.004
PMID: 31306988
Source
Medline
Language
English
License
Unknown

Abstract

Neural crest cells are a multipotent embryonic stem cell population that migrate large distances to contribute a variety of tissues. The cranial neural crest, which contribute to tissues of the face and skull, undergo collective migration whose movement has been likened to cancer metastasis. Over the last few years, a variety of mechanisms for the guidance of collective cranial neural crest cell migration have been described: mostly chemical, but more recently mechanical. Here we review these different mechanisms and attempt to integrate them to provide a unified model of collective cranial neural crest cell migration. Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

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