In work-from-home (WFH) situation due to coronavirus (COVID-19) pandemic, the handheld device (HHD) users work in awkward postures for longer hours because of unavailability of ergonomically designed workstations. This problem results in different type of musculoskeletal disorders (MSDs) among the HHD users. An integrated multi-criteria decision-making approach was offered for identifying the risk level of MSDs among HHD users. A case example implemented the proposed approach in which, firstly, the best–worst method (BWM) technique was used to prioritize and determine the relative importance (weightage) of the risk factors. The weightages of the risk factors further used to rank the seven alternatives (HHD users) using Vlse Kriterijumska Optimizacija Kompromisno Resenje (VIKOR) technique. The outcomes of the BWM investigation showed that the three most significant risk factors responsible for MSDs are duration of working, poor working posture and un-ergonomic design. The outcome of the VIKOR technique exhibited that computer professionals were at the highest risk among all users. The risk factor priority must be used for designing a working strategy for the WFH situation which will help to mitigate the risks of MSDs.