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Integrated microfluidic system for electrochemical sensing of urinary proteins.

Authors
  • Liu, Cheng-Yu
  • Rick, John
  • Chou, Tse-Chuan
  • Lee, Huei-Huang
  • Lee, Gwo-Bin
Type
Published Article
Journal
Biomedical Microdevices
Publisher
Springer-Verlag
Publication Date
Feb 01, 2009
Volume
11
Issue
1
Pages
201–211
Identifiers
DOI: 10.1007/s10544-008-9225-0
PMID: 18792782
Source
Medline
License
Unknown

Abstract

This study reports a new microfluidic system integrated with a microfluidic control module and a micro electrochemical module for detection of urinary proteins. The integrated microsystem can automatically detect proteins in urine with a high sensitivity. The microfluidic control module consists of a new two-way, spiral-shape micropump which can transport the urine samples to the sensing regions. The net ionic charges of the protein samples can be detected while the samples flow through the sensing region of the micro electrochemical module. Two major urinary proteins including lysozyme and albumin are detected in a multiple-channel layout with little human intervention and are analyzed in a short period of time, while only consuming a 100-mul urine sample. The developed microfluidic system could lead to a convenient, yet crucial, platform for chemical and biological detection and diagnosis.

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