Effective and timely exchange of information among healthcare, state and local public health, and other health emergency response partners is essential to all-hazards emergency preparedness and response. Since fall of 2001, NY State Department of Health has partnered with the healthcare and public health community in New York to implement a statewide Health Emergency Response Data System to meet this need. During this time, it has been used in a wide range of preparedness and response applications including regional and local exercises, surveillance, health facility asset tracking, and response to actual health events. The architecture, design, and implementation model used in the system readily support all-hazards preparedness and response at state, regional, and local levels. It has become one of the most important assets to health emergency response in New York State.