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An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes

  • Zhu, Anlian
  • Li, Lingjun
  • Zhang, Chi
  • Shen, Yutan
  • Tang, Mingjie
  • Bai, Lili
  • Du, Chunyan
  • Zhang, Suojiang
  • Wang, Jianji
Publication Date
Jan 21, 2019
Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
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Development of new chemical processes with simplified reaction systems and work-up procedures is a challenging task. Although ionic liquids are a class of potential multifunctional compounds to simplify traditional chemical processes, their rational design is difficult due to complex interactions. In this work, a proof-of-concept strategy has been proposed to achieve an integration of high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonylazide cycloaddition reactions. Merits of the ionic liquids-based processes have been demonstrated not only in the convenient and efficient synthesis of 1,2,3-triazolyl compounds but also in the discovery of a new reaction for the chemical post-modification of free peptides.

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