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Integrated analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy.

Authors
  • Qiao, Song1
  • Xu, Qi2
  • Cheng, Lin1
  • Zhang, Ying3
  • Liu, Xiaoli1
  • Zheng, Chaobo1
  • Hu, Xiaofeng4
  • Chen, Linhui1
  • 1 Department of Neurology, Zhejiang Hospital, Hangzhou, 310000, Zhejiang, China. , (China)
  • 2 Department of Radiology, Zhejiang Hospital, Hangzhou, 310000, Zhejiang, China. , (China)
  • 3 Department of Neurology, Second Affiliated Hospital of Zhejiang University, Hangzhou, 310000, Zhejiang, China. , (China)
  • 4 Department of Cardiology, Zhejiang Hospital, Hangzhou, 310000, Zhejiang, China. , (China)
Type
Published Article
Journal
Neuro endocrinology letters
Publication Date
May 01, 2018
Volume
39
Issue
2
Pages
119–124
Identifiers
PMID: 30183206
Source
Medline
Language
English
License
Unknown

Abstract

Medial temporal lobe epilepsy (MTLE) is the most frequent type of epilepsy. In recent years, the important roles of lncRNAs in regulating human diseases progression had been implicated, including in epilepsy. However, comprehensive analysis of differentially expressed lncRNAs in Medial Temporal Lobe Epilepsy was still lacking. The aim of this study was to explore relevant lncRNAs in MTLE. In present study, we analyzed a public dataset GSE25453 to identify differentially expressed lncRNAs and mRNAs in the MTLE. A total of 16 lncRNAs (C6orf176, NCRNA00259, PRO1768, TTTY11, LOC149620, GDEP, LOC400891, HLA-DRB6, TTTY21, TTTY3, NBR2, TTTY1, FAM183B, C15orf51, FAM74A3, and MALAT1) were identified. LncRNA co-expression network analysis showed these lncRNAs were mainly enriched in regulating transcription, inflammatory response, DNA binding, Jak Stat Signaling Pathway, and Mapk Signaling Pathway. Meanwhile, lncRNA-mRNA-biological processes networks were also performed to evaluate the potential roles of key lncRNAs in MTLE. This study will be useful to explore the potential candidate biomarkers for diagnosis, prognosis, and drug targets of MTLE.

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