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Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor.

Authors
  • Bauer, Todd W
  • Fan, Fan
  • Liu, Wenbiao
  • Johnson, Marjorie
  • Parikh, Nila U
  • Parry, Graham C
  • Callahan, Jennifer
  • Mazar, Andrew P
  • Gallick, Gary E
  • Ellis, Lee M
Type
Published Article
Journal
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 30, 2005
Volume
241
Issue
5
Identifiers
PMID: 15849510
Source
Medline
License
Unknown

Abstract

IGF-I and HGF cooperate to induce migration and invasion of CRC cells, and c-Met and uPA/uPAR are required for IGF-I-mediated migration and invasion. In our in vitro model of CRC migration and invasion, uPA and uPAR appear to be downstream of IGF-IR and c-Met and are required for migration and invasion. Elucidation of the pathways that contribute to tumor progression and metastasis should provide a foundation for the rational development and use of targeted therapies for CRC.

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