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Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women.

Authors
  • Lee, Seung Eun1
  • Baek, Ji Yeon2
  • Han, Kyungdo3
  • Koh, Eun Hee2
  • 1 Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea. , (North Korea)
  • 2 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , (North Korea)
  • 3 Department of Biostatistics, The Catholic University of Korea, Seoul, Korea. , (North Korea)
Type
Published Article
Journal
Diabetes & metabolism journal
Publication Date
Mar 01, 2021
Volume
45
Issue
2
Pages
175–182
Identifiers
DOI: 10.4093/dmj.2019.0150
PMID: 32431107
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal status. A total of 1,700 adults from the 2010 Korean National Health and Nutrition Examination Survey were classified into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) by body mass index and insulin resistance. Atopy was defined as a positive response to at least one aeroallergen. Multiple regression analysis was used to evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the degree of metabolic abnormality and obesity. In premenopausal women, total IgE was positively correlated with obesity and insulin resistance. MUNO participants had a higher risk of having elevated total IgE compared to MHNO participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 4.294), while MHO participants did not show a significant difference (OR, 1.435; 95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and postmenopausal women, there was no significant difference between metabolic status, obesity, and atopy among groups. Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men.

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