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Insulin resistance despite tight glucose control is associated with mortality in critically ill surgical patients.

Authors
  • Mowery, Nathan T
  • Dortch, Marcus J
  • Dossett, Lesly A
  • Norris, Patrick R
  • Diaz, Jose J Jr
  • Morris, John A Jr
  • May, Addison K
Type
Published Article
Journal
Journal of intensive care medicine
Publication Date
Jan 01, 2009
Volume
24
Issue
4
Pages
242–251
Identifiers
DOI: 10.1177/0885066609335663
PMID: 19617231
Source
Medline
License
Unknown

Abstract

There was a large amount of variation in insulin resistance, as measured by an adapting multiplier, both across the population and within patients. In the setting of tight glucose control measures of glucose control (median blood glucose and percent in range) do not differentiate between patients who lived and died while measures of insulin resistance (median insulin dose and multiplier) do, suggesting that the insulin resistance is a better predictor of outcome.

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