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Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

Authors
  • Grosse, Johannes
  • Heffron, Helen
  • Burling, Keith
  • Akhter Hossain, Mohammed
  • Habib, Abdella M
  • Rogers, Gareth J
  • Richards, Paul
  • Larder, Rachel
  • Rimmington, Debra
  • Adriaenssens, Alice A
  • Parton, Laura
  • Powell, Justin
  • Binda, Matteo
  • Colledge, William H
  • Doran, Joanne
  • Toyoda, Yukio
  • Wade, John D
  • Aparicio, Samuel
  • Carlton, Mark B L
  • Coll, Anthony P
  • And 3 more
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Jul 28, 2014
Volume
111
Issue
30
Pages
11133–11138
Identifiers
DOI: 10.1073/pnas.1411413111
PMID: 25028498
Source
Medline
License
Unknown

Abstract

The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lacking the cognate receptor Rxfp4. Plasma Insl5 levels were elevated by fasting or prolonged calorie restriction, and declined with feeding. We conclude that Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.

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