Affordable Access

deepdyve-link
Publisher Website

Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age.

Authors
  • van der Kaay, Daniëlle
  • Deal, Cheri
  • de Kort, Sandra
  • Willemsen, Ruben
  • Leunissen, Ralph
  • Ester, Wietske
  • Paquette, Jean
  • van Doorn, Jaap
  • Hokken-Koelega, Anita
Type
Published Article
Journal
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Publication Date
Apr 01, 2009
Volume
94
Issue
4
Pages
1386–1392
Identifiers
DOI: 10.1210/jc.2008-1430
PMID: 19158202
Source
Medline
License
Unknown

Abstract

Normal IGFBP-1 levels in lean, short, SGA children may reflect a normal metabolic state, despite reported hyperinsulinemia. IGFBP-1 is modulated by polymorphic variability and seems to be an additional player in the complex interaction between the IGF-IGFBP axis, glucose homeostasis, and lipid metabolism.

Report this publication

Statistics

Seen <100 times