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Insulin-like growth factor binding protein-1 in NIDDM: relationship with the insulin resistance syndrome.

Authors
  • Mohamed-Ali, V
  • Pinkney, J H
  • Panahloo, A
  • Cwyfan-Hughes, S
  • Holly, J M
  • Yudkin, J S
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Feb 01, 1999
Volume
50
Issue
2
Pages
221–228
Identifiers
PMID: 10396366
Source
Medline
License
Unknown

Abstract

In NIDDM, concentrations of IGFBP-1 are related to those of insulin, insulin sensitivity, serum lipoproteins and PAI-1 activity. The relationship between concentrations of IGFBP-1 and HDL-cholesterol is not explained by insulin. Concentrations of IGF-1 are linked to HDL-cholesterol, and this is not explained by levels of IGFBP-1. IGFBP-1 concentrations were related to PAI-1 activity, and this may be explained by insulin, which regulates the production of IGFBP-1 and PAI-1.

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