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Insulin-like growth factor-1 retinal microangiopathy in the pig eye.

Authors
  • Danis, R P
  • Bingaman, D P
Type
Published Article
Journal
Ophthalmology
Publisher
Elsevier
Publication Date
Oct 01, 1997
Volume
104
Issue
10
Pages
1661–1669
Identifiers
PMID: 9331208
Source
Medline
License
Unknown

Abstract

A single intravitreous injection of a large dose of hrIGF-1 produces a retinal microangiopathy that has a prolonged time of onset and remains stable from 2 to 6 months after injection. Some aspects of this angiopathy resemble diabetic retinopathy, suggesting growth factor effects in the morphologic vascular changes of diabetes.

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