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Insulin-dependent diabetes mellitus associated with autoimmune thyroiditis and rheumatoid arthritis.

Authors
  • Yamato, E
  • Ikegami, H
  • Kawaguchi, Y
  • Fujisawa, T
  • Hamada, Y
  • Ueda, H
  • Shintani, M
  • Ogihara, T
Type
Published Article
Journal
The American Journal of the Medical Sciences
Publisher
Elsevier
Publication Date
Jan 01, 1997
Volume
313
Issue
1
Pages
64–66
Identifiers
PMID: 9001168
Source
Medline
License
Unknown

Abstract

A case associated with insulin-dependent diabetes mellitus (IDDM), rheumatoid arthritis (RA), and autoimmune thyroid disease (AITD) was reported. A high titer of anti-glutamic acid decarboxylase antibody (GAD) and a positive islet cell antigen were observed. The patient's human leukocyte antibody (HLA) haplotype was a homozygote of DQA1*0301, DQB1*0401, and DRB1*0405. Because this haplotype was in linkage disequilibrium with DPB1*0501, an allele associated with AITD in Japanese patients, the patient was homozygous for alleles susceptible to IDDM, RA, and AITD. A specific HLA haplotype susceptible to several autoimmune disease may result in the development of IDDM, RA, and AITD.

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