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inSilicoDb: an R/Bioconductor package for accessing human Affymetrix expert-curated datasets from GEO.

Authors
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Volume
27
Issue
22
Pages
3204–3205
Identifiers
DOI: 10.1093/bioinformatics/btr529
PMID: 21937664
Source
Medline
License
Unknown

Abstract

Microarray technology has become an integral part of biomedical research and increasing amounts of datasets become available through public repositories. However, re-use of these datasets is severely hindered by unstructured, missing or incorrect biological samples information; as well as the wide variety of preprocessing methods in use. The inSilicoDb R/Bioconductor package is a command-line front-end to the InSilico DB, a web-based database currently containing 86 104 expert-curated human Affymetrix expression profiles compiled from 1937 GEO repository series. The use of this package builds on the Bioconductor project's focus on reproducibility by enabling a clear workflow in which not only analysis, but also the retrieval of verified data is supported.

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