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Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status.

Authors
  • Rafael, Marta S
  • Cavaco, Sofia
  • Viegas, Carla S B
  • Santos, Sofia
  • Ramos, Acácio
  • Willems, Brecht A G
  • Herfs, Marjolein
  • Theuwissen, Elke
  • Vermeer, Cees
  • Simes, Dina C
Type
Published Article
Journal
Molecular Nutrition & Food Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2014
Volume
58
Issue
8
Pages
1636–1646
Identifiers
DOI: 10.1002/mnfr.201300941
PMID: 24867294
Source
Medline
Keywords
License
Unknown

Abstract

Overall, our results indicate the predominance of GRP-F1, and a clear association of ucGRP with OA cartilage and synovial membrane. Levels of vitamin K should be further assessed in these patients to determine its potential therapeutic use as a supplement in OA treatment.

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