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Insight into the Sialome of the Bed Bug, Cimex lectularius.

Authors
  • Francischetti, Ivo M B
  • Calvo, Eric
  • Andersen, John F
  • Pham, Van M
  • Favreau, Amanda J
  • Barbian, Kent D
  • Romero, Alvaro
  • Valenzuela, Jesus G
  • Ribeiro, José M C
Type
Published Article
Journal
Journal of Proteome Research
Publisher
American Chemical Society
Publication Date
Aug 06, 2010
Volume
9
Issue
8
Pages
3820–3831
Identifiers
DOI: 10.1021/pr1000169
PMID: 20441151
Source
Medline
License
Unknown

Abstract

The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts' hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100 different polypeptides is commonly found by transcriptome or proteome analysis of these organisms. Several insect orders or families evolved independently to hematophagy, creating unique salivary potions in the form of novel pharmacological use of endogenous substances and in the form of unique proteins not matching other known proteins, these probably arriving by fast evolution of salivary proteins as they evade their hosts' immune response. In this work we present a preliminary description of the sialome (from the Greek Sialo = saliva) of the common bed bug Cimex lectularius, the first such work from a member of the Cimicidae family. This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/transcriptome/C_lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/transcriptome/C_lectularius/S2/Cimex-S2.xls.

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