Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination.
- Published Article
The journal of gene medicine
- Publication Date
Jan 01, 1999
Instability of a plasmid vector for gene therapy has been minimized by rational modification. The introduction of an intron for this purpose offers the additional advantage of providing a discriminatory RT-PCR assay.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10738548