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Insecticidal Activity of Doxycycline against the Common Bedbug.

Authors
  • Pietri, Jose E1
  • Liang, Dangsheng2
  • 1 University of South Dakota, Sanford School of Medicine, Division of Basic Biomedical Sciences, South Dakota, USA [email protected]
  • 2 Apex Bait Technologies, Inc., Santa Clara, California, USA.
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Apr 21, 2020
Volume
64
Issue
5
Identifiers
DOI: 10.1128/AAC.00005-20
PMID: 32122896
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

There is an ongoing need for safe and effective anti-bedbug compounds. Here, we tested the toxicity of three antimicrobial agents against bedbugs when administered orally. We reveal that doxycycline has direct insecticidal activity at 250 μg/ml (0.025%) that is particularly strong against immature bedbugs and appears to be independent of antimicrobial activity. Future studies to determine the mechanisms behind this property could be useful for the development of orally active insecticides or anti-bedbug therapeutics. Copyright © 2020 American Society for Microbiology.

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