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Insect anaphylaxis: addressing clinical challenges.

Authors
  • Tracy, James M
  • Lewis, Elena J
  • Demain, Jeffrey G
Type
Published Article
Journal
Current Opinion in Allergy and Clinical Immunology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Aug 01, 2011
Volume
11
Issue
4
Pages
332–336
Identifiers
DOI: 10.1097/ACI.0b013e32834877ab
PMID: 21659864
Source
Medline
License
Unknown

Abstract

Mast cell disease, serum tryptase and basophil biology are providing an opportunity to better understand and manage insect allergy. This evolving understanding should improve long-term management of insect anaphylaxis and help us to better understand the clinical dilemma of appropriate management of the history-positive patient in which testing is unable to detect venom-specific IgE. Furthermore, omalizumab's immunomodulatory effects may play a role in difficult-to-treat insect allergy and mastocytosis. Finally, unrelated to these, but still important as an ongoing risk factor, is the continued underutilization of epinephrine for both acute and long-term management of insect anaphylaxis.

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