Affordable Access

deepdyve-link
Publisher Website

Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila

Authors
  • Otto, Nils1
  • Pleijzier, Markus W.2
  • Morgan, Isabel C.1
  • Edmondson-Stait, Amelia J.2
  • Heinz, Konrad J.2
  • Stark, Ildiko2
  • Dempsey, Georgia2
  • Ito, Masayoshi3
  • Kapoor, Ishaan1
  • Hsu, Joseph3
  • Schlegel, Philipp M.2, 4
  • Bates, Alexander S.2, 4
  • Feng, Li3
  • Costa, Marta2
  • Ito, Kei5
  • Bock, Davi D.3
  • Rubin, Gerald M.3
  • Jefferis, Gregory S.X.E.2, 4
  • Waddell, Scott1
  • 1 Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK
  • 2 Drosophila Connectomics, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
  • 3 Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA
  • 4 B2 0QH, UK
  • 5 Institute for Zoology, University of Cologne, Zülpicher Straße 47b, 50674 Cologne, Germany
Type
Published Article
Journal
Current Biology
Publisher
Cell Press
Publication Date
Aug 17, 2020
Volume
30
Issue
16
Pages
3200–3211
Identifiers
DOI: 10.1016/j.cub.2020.05.077
PMID: 32619479
PMCID: PMC7443709
Source
PubMed Central
Keywords
License
Unknown

Abstract

Otto et al. use electron microscope resolution connectomics to describe the structure and organization of neurons providing synaptic input to functionally discrete subtypes of dopaminergic neurons. The nanoscale anatomy reveals further anatomical and functional specialization of dopaminergic neurons, which is confirmed with behavioral experiments.

Report this publication

Statistics

Seen <100 times