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INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division.

Authors
  • Gowans, Graeme J1
  • Schep, Alicia N2
  • Wong, Ka Man1
  • King, Devin A1
  • Greenleaf, William J2
  • Morrison, Ashby J3
  • 1 Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • 2 Department of Genetics, Stanford University, Stanford, CA 94305, USA.
  • 3 Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: [email protected]
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jan 16, 2018
Volume
22
Issue
3
Pages
611–623
Identifiers
DOI: 10.1016/j.celrep.2017.12.079
PMID: 29346761
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression in coordination with respiration and cell division in the yeast metabolic cycle (YMC). Despite the importance of metabolic and proliferative synchrony, the majority of YMC regulators are currently unknown. Here, we demonstrate that the INO80 chromatin-remodeling complex is required to coordinate respiration and cell division with periodic gene expression. Specifically, INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. In mutant cells, chromatin accessibility of periodic genes, including TORC1-responsive genes, is relatively static, concomitant with severely attenuated gene expression. Collectively, these results reveal that the INO80 complex mediates metabolic signaling to chromatin to restrict proliferation to metabolically optimal states. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

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