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Innovation of Expanded-Bed Adsorption by Integrating Simulated Moving-Bed Technology.

Authors
  • Pathapati, Trinath1
  • Rutze, Dennis N1
  • de Wit, Pieter1
  • den Boer, Piet1
  • Zaalberg, Menne1
  • 1 Xendo B.V. Bio Science Park, Schipholweg 73-75 2316 ZL Leiden The Netherlands. , (Netherlands)
Type
Published Article
Journal
Chemical engineering & technology
Publication Date
Dec 01, 2018
Volume
41
Issue
12
Pages
2393–2401
Identifiers
DOI: 10.1002/ceat.201800293
PMID: 31007406
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Bio-based industries need efficient downstream solutions to process complex streams. This was addressed through a technology integration approach, where expanded-bed adsorption (EBA) is integrated with simulated moving-bed (SMB) technology. Current work involved adaptation of an SMB apparatus and control principle to implement expanded-bed level control. As an outcome, EBA-SMB technology was successfully applied for purification of γ-aminobutyric acid (GABA). This resulted in two-fold increase in productivity and a GABA purity ≥ 92 % in one step from unclarified fermentation broth, compared to ≥ 93 % purity in case of clarified broth and packed-bed SMB. These results proved that EBA-SMB technology is able to enhance process efficiency and economics of bioprocesses.

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