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The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients.

Authors
  • Ezzelarab, Mohamed
  • Garcia, Bertha
  • Azimzadeh, Agnes
  • Sun, Hongtao
  • Lin, Chih Che
  • Hara, Hidetaka
  • Kelishadi, Sean
  • Zhang, Tianshu
  • Lin, Yih Jyh
  • Tai, Hao-Chi
  • Wagner, Robert
  • Thacker, Jnanesh
  • Murase, Noriko
  • McCurry, Kenneth
  • Barth, Rolf N
  • Ayares, David
  • Pierson, Richard N 3rd
  • Cooper, David K C
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 27, 2009
Volume
87
Issue
6
Pages
805–812
Identifiers
DOI: 10.1097/TP.0b013e318199c34f
PMID: 19300181
Source
Medline
License
Unknown

Abstract

Our data suggest that (1) irrespective of the presence or absence of the adaptive immune response, early or late xenograft rejection is associated with activation of the innate immune system; and (2) porcine endothelial cell activation and primate TF expression by recipient innate immune cells may both contribute to the development of TM.

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