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Innate Immune Dysregulation in the Development of Cardiovascular Disease in Lupus

Authors
  • Tumurkhuu, Gantsetseg1
  • Montano, Erica1
  • Jefferies, Caroline1
  • 1 Cedars-Sinai Medical Center, Department of Medicine, Division of Rheumatology and Department of Biomedical Sciences, Los Angeles, CA, USA , Los Angeles (United States)
Type
Published Article
Journal
Current Rheumatology Reports
Publisher
Springer-Verlag
Publication Date
Jul 23, 2019
Volume
21
Issue
9
Identifiers
DOI: 10.1007/s11926-019-0842-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewThe systemic inflammatory nature of systemic lupus erythematosus (SLE) is patent not only in the diverse clinical manifestations of the disease but also in the increased risk of premature cardiovascular diseases (CVD). In this review, we discuss the latest findings on the key factors of the innate immune system known to play critical roles in the pathogenesis of accelerated CVD in patients with SLE and discuss the potential that immunometabolism may play a key role in this respect.Recent FindingsRecent studies exploring the association between SLE and premature CVD clearly showed that alterations of specific immune functions play a pivotal role in the increased cardiovascular morbidity and mortality in the SLE patients. Novel molecular factors such as type I interferons (IFN), dysregulated neutrophil function, and changes to cellular metabolism and metabolites are emerging as important regulators of systemic immune dysfunction and as strong risk factors for premature CVD in SLE.SummaryAlthough corticosteroids and cytotoxic agents can be used to effectively manage and control various lupus-related complications, to date, no drug has been proven to prevent the development of premature atherosclerosis in SLE. However, as new mechanisms underlying this complication of SLE are uncovered, such as the role of metabolism and neutrophil-driven inflammation, new avenues for therapeutic intervention are being discovered.

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