Affordable Access

Access to the full text

Innate and adaptive immunity: specificities and signaling hierarchies revisited

Authors
  • Vivier, Eric1
  • Malissen, Bernard1
  • 1 Centre d'Immunologie de Marseille-Luminy, INSERM–CNRS–Univ. Méditerranée, Campus de Luminy, case 906, Marseille, 13288Cedex 09, France , Marseille (France)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Dec 20, 2004
Volume
6
Issue
1
Pages
17–21
Identifiers
DOI: 10.1038/ni1153
Source
Springer Nature
License
Yellow

Abstract

The conventional classification of known immune responses by specificity may need re-evaluation. The immune system can be classified into two subsystems: the innate and adaptive immune systems. In general, innate immunity is considered a nonspecific response, whereas the adaptive immune system is thought of as being very specific. In addition, the antigen receptors of the adaptive immune response are commonly viewed as 'master sensors' whose engagement dictates lymphocyte function. Here we propose that these ideas do not genuinely reflect the organization of immune responses and that they bias our view of immunity as well as our teaching of immunology. Indeed, the level of specificity and mode of signaling integration used by the main cellular participants in the adaptive and innate immune systems are more similar than previously appreciated.

Report this publication

Statistics

Seen <100 times