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Injectables and Depots to Prolong Drug Action of Proteins and Peptides

Authors
  • Ibeanu, Nkiruka1,
  • Egbu, Raphael1
  • Onyekuru, Lesley1
  • Javaheri, Hoda1
  • Tee Khaw, Peng
  • R. Williams, Gareth1
  • Brocchini, Steve1,
  • Awwad, Sahar1,
  • 1 (S.B.)
Type
Published Article
Journal
Pharmaceutics
Publisher
MDPI
Publication Date
Oct 21, 2020
Volume
12
Issue
10
Identifiers
DOI: 10.3390/pharmaceutics12100999
PMID: 33096803
PMCID: PMC7589296
Source
PubMed Central
Keywords
License
Green

Abstract

Proteins and peptides have emerged in recent years to treat a wide range of multifaceted diseases such as cancer, diabetes and inflammation. The emergence of polypeptides has yielded advancements in the fields of biopharmaceutical production and formulation. Polypeptides often display poor pharmacokinetics, limited permeability across biological barriers, suboptimal biodistribution, and some proclivity for immunogenicity. Frequent administration of polypeptides is generally required to maintain adequate therapeutic levels, which can limit efficacy and compliance while increasing adverse reactions. Many strategies to increase the duration of action of therapeutic polypeptides have been described with many clinical products having been developed. This review describes approaches to optimise polypeptide delivery organised by the commonly used routes of administration. Future innovations in formulation may hold the key to the continued successful development of proteins and peptides with optimal clinical properties.

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