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Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials.

Authors
  • Rabinowitz, Jonathan1
  • Werbeloff, Nomi2
  • Mandel, Francine S2
  • Menard, François2
  • Marangell, Lauren2
  • Kapur, Shitij2
  • 1 Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, University of Texas Health Science Center, Houston, Texas, USA; Shitij Kapur, MD, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK [email protected] , (France)
  • 2 Jonathan Rabinowitz, PhD, Nomi Werbeloff, PhD, School of Social Work, Ramat Gan, Bar Ilan University, Israel; Francine S. Mandel, PhD, Pfizer Development Operations, New York, USA; François Menard, MD, Lundbec Research Department, Paris, France; Lauren Marangell, MD, Department of Psychiatry, University of Texas Health Science Center, Houston, Texas, USA; Shitij Kapur, MD, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK. , (France)
Type
Published Article
Journal
The British journal of psychiatry : the journal of mental science
Publication Date
Nov 01, 2016
Volume
209
Issue
5
Pages
427–428
Identifiers
PMID: 27198482
Source
Medline
License
Unknown

Abstract

Several often-cited meta-analyses have reported that the efficacy of antidepressant medications depends on the severity of depression. They found that drug-placebo differences increased as a function of initial severity, which was attributed to decreased responsiveness to placebo among patients with severe depression rather than to increased responsiveness to medication. We retested this using patient-level data and also undertaking a meta-analysis of trial-level data from 34 randomised placebo controlled trials (n = 10 737) from the NEWMEDS registry. Although our trial-level data support prevous findings, patient-level data did not show any significant effect of initial depression severity on drug v. placebo difference.

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