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Inhibitory effects of urinary macromolecules on the crystallization of calcium oxalate.

Authors
  • Gill, W B
  • Karesh, J W
  • Garsin, L
  • Roma, M J
Type
Published Article
Journal
Investigative urology
Publication Date
Sep 01, 1977
Volume
15
Issue
2
Pages
95–99
Identifiers
PMID: 903217
Source
Medline
License
Unknown

Abstract

Protective (inhibitory) effects of human urinary macromolecules on the crystallization of calcium oxalate were found when these urinary macromolecules were added to water or to salt solutions, which mimic human urine with respect to the concentrations of the most abundant small molecular weight species. The aspects of calcium oxalate crystallization affected by urinary macromolecules were: (i) an inhibition of nucleation (increased metastable limit), (ii) an inhibition of the crystallization rate, (iii) a decrease in the supersaturation level, and (iv) a decrease in adhesion of crystals to container surfaces.

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