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Inhibitory effects of bisdemethoxycurcumin on mast cell-mediated allergic diseases.

Authors
  • Fu, Meng1
  • Fu, Shuilian1
  • Ni, Saihong1
  • Wang, Danni1
  • Hong, Tie2
  • 1 Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China. , (China)
  • 2 Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
International immunopharmacology
Publication Date
Dec 01, 2018
Volume
65
Pages
182–189
Identifiers
DOI: 10.1016/j.intimp.2018.10.005
PMID: 30316076
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Most allergic reactions are induced by mast cell activation. Mast cells play vital roles in the pathogenesis of allergic diseases. Bisdemethoxycurcumin (BDMC), a natural curcuminoid, has potential anti-allergic effects. Hence, we explored the effect of BDMC on mast cell-mediated allergic diseases. The study proved that BDMC suppresses β-hexosaminidase release, granule release, and membrane ruffling in monoclonal anti-2,4,6-dinitrophenyl-immunoglobulin (Ig) E/human serum albumin (DNP-IgE/HSA)-stimulated rat basophilic leukaemia cells (RBL-2H3 cells), and BDMC suppressed ovalbumin (OVA)-induced allergic rhinitis (AR) symptoms and OVA-specific IgE levels in AR mice. Furthermore, BDMC increased the survival of compound 48/80 anaphylaxis shock mice and elevated the decreased rectal temperature in OVA-induced active systemic anaphylaxis mice. These findings indicate that BDMC regulates the degranulation of mast cells, demonstrating its potential in the treatment of mast cell-induced allergic reactions. Copyright © 2018 Elsevier B.V. All rights reserved.

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